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Glucose transporter expression and glucose utilization in skeletal muscle and brown adipose tissue during starvation and re-feeding.

机译:饥饿和重新进食期间骨骼肌和棕色脂肪组织中的葡萄糖转运蛋白表达和葡萄糖利用率。

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摘要

Starvation (48 h) decreased the concentration of mRNA of the insulin-responsive glucose transporter isoform (GLUT 4) in interscapular brown adipose tissue (IBAT) (56%) and tibialis anterior (10%). Despite dramatic [7-fold (tibialis anterior) and 40-fold (IBAT)] increases in glucose utilization after 2 and 4 h of chow re-feeding, no significant changes in GLUT 4 mRNA concentration were observed in these tissues over this re-feeding period. The results exclude changes in GLUT 4 mRNA concentration in mediating the responses of glucose transport in these tissues to acute re-feeding after prolonged starvation.
机译:饥饿(48小时)降低了肩inter间棕色脂肪组织(IBAT)(56%)和胫骨前肌(10%)中胰岛素反应性葡萄糖转运蛋白亚型(GLUT 4)的mRNA浓度。尽管在进食2和4小时后,葡萄糖利用率显着增加[胫骨前部(7倍)和(IBAT)40倍],但是在这段时间内,这些组织中未观察到GLUT 4 mRNA浓度的显着变化。喂养期。结果排除了长期饥饿后介导这些组织中葡萄糖转运对急性再进食的反应中GLUT 4 mRNA浓度的变化。

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